منابع مشابه
The global impact of drug resistance.
Measuring the impact of drug resistance is an important step in understanding the scope of the problem and formulating policies to limit the emergence and spread of resistant organisms. Studies have focused on measuring the increased costs, morbidity, and mortality in patients with infections due to resistant versus susceptible organisms. These have generally found that resistance worsens outco...
متن کاملReversibility of HIV drug resistance.
Using a mathematical model, Blower et al. (1) predicted the impact of antiretroviral therapy (ART) on future trends in the sexual spread of human immunodeficiency virus (HIV). The model employed Latin hypercube sampling to allow for the high degree of uncertainty in the estimation of many model parameters. The authors incorporated into their model the assumption that patients with drug-resistan...
متن کاملAcute HIV infection: impact on the spread of HIV and transmission of drug resistance.
OBJECTIVE To assess the impact of primary HIV infection (PHI) on the spread of HIV and the temporal trends in transmission of HIV drug resistance between 1996 and 1999 in Switzerland. METHODS Sequencing of the genes for reverse transcriptase (RT) and protease was performed for 197 individuals with documented PHI. Phylogenetic analyses were confronted with epidemiological data. RESULTS Signi...
متن کاملHIV drug resistance in HIV-infected children.
Almeida et al. report, in this issue of the journal, a retrospective studyon theprevalence and patterns of antiretroviral drug resistance in 24 treatment-naïve and 23 treatment-experienced children failing therapy between 2000 and 2004 attending a clinic in São Paulo. All children were vertically infected, and the median age of the naïveand treatment-experienced children was 22 months and 102 m...
متن کاملDrug Resistance in Non-B Subtype HIV-1: Impact of HIV-1 Reverse Transcriptase Inhibitors
Human immunodeficiency virus (HIV) causes approximately 2.5 million new infections every year, and nearly 1.6 million patients succumb to HIV each year. Several factors, including cross-species transmission and error-prone replication have resulted in extraordinary genetic diversity of HIV groups. One of these groups, known as group M (main) contains nine subtypes (A-D, F-H and J-K) and causes ...
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ژورنال
عنوان ژورنال: Journal of the International AIDS Society
سال: 2008
ISSN: 1758-2652
DOI: 10.1186/1758-2652-11-s1-o1